Angiopoietin concentrations in diabetic retinopathy
نویسندگان
چکیده
منابع مشابه
Angiopoietin concentrations in diabetic retinopathy.
BACKGROUND/AIM Angiopoietin 1 and 2 interact with vascular endothelial growth factor (VEGF) to promote angiogenesis in animal and in vitro models. Although VEGF concentrations are elevated, there is little information regarding angiopoietin concentration in the vitreous of patients with diabetic retinopathy. METHODS Angiopoietin concentrations were measured by luminescence immunoassay in vitr...
متن کاملSerum and Vitreous Concentrations of Omentin-1 in Diabetic Retinopathy
OBJECTIVE Omentin, a new discovered adipokine, is implicated to inhibit inflammation. Inflammation is one important mechanism of diabetic retinopathy (DR). The purpose of this work was to evaluate serum and vitreous concentrations of omentin-1 in patients with diabetic retinopathy (DR). METHODS This study enrolled 204 diabetic patients (60 without DR, 49 with NPDR, and 95 with PDR) and 65 con...
متن کاملAngiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.
Pericyte loss is an early pathologic feature of diabetic retinopathy, consistently present in retinae of diabetic humans and animals. Because pericyte recruitment and endothelial cell survival are controlled, in part, by the angiopoietin/Tie2 ligand/receptor system, we studied the expression of angiopoietin-2 and -1 in relation to the evolution of pericyte loss in diabetic rat retinae, using qu...
متن کاملAngiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy.
Pericyte loss is an early characteristic change in diabetic retinopathy (DR). Despite accumulating evidence that hyperglycemia-induced angiopoietin 2 (Ang2) has a central role in pericyte loss, the precise molecular mechanism has not been elucidated. This study investigated the role of Ang2 in pericyte loss in DR. We demonstrated that pericyte loss occurred with Ang2 increase in the diabetic mo...
متن کاملThe angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy.
PURPOSE The angiopoietin (Ang) system plays an important role in vascular stabilization and pathologic neovascularization. The hypothesis for the study was that, in addition to modulating endothelial cell behavior, the angiopoietin/Tie-2 system also regulates the pericyte apoptosis and/or the vessel maturation associated with diabetic retinopathy. METHODS Tie-2 expression in cultured retinal ...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2005
ISSN: 0007-1161
DOI: 10.1136/bjo.2004.049940